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In recent years, retail drug spending has become one of the fastest areas for spending growth in the Commonwealth, with accompanying effects on patient affordability through increases in cost-sharing

They represent the current front line of effective weight loss medications, but they work through slightly different mechanisms and have distinct approval histories

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Evidence Behind Semaglutide and Tirzepatide Efficacy in Real-World Use Clinical trials demonstrate semaglutide achieves average weight loss of 9-17% at maintenance doses, with higher percentages in longer studies

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