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Importantly, none of these mechanistic observations confirm clinical effectiveness in humans

[3] Glucocorticoids (like prednisolone) are among the most common causes of secondary osteoporosis, and they work partly by suppressing GH/IGF-1 signaling

However, a manual search of high throughput gene expression data (NCBI GEO database) (Edgar et al., 2002) did not indicate experimental conditions that revealed substantial cntA gene transcription under in vivo conditions

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A facility can continue operating while responding to warning letters, negotiating corrective actions, and disputing findings