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2023;12(1) doi: 10.1161/JAHA.121.025064

NICE approved semaglutide (Wegovy) for weight management in specialist NHS weight management services in 2023 (TA875), but availability is limited to patients with: BMI 35 kg/m with at least one weight-related comorbidity, or BMI 30 kg/m with exceptional circumstances Lower BMI thresholds apply for people from some minority ethnic groups (typically 27.5 kg/m) Participation in a specialist weight management programme Treatment limited to a maximum of 2 years Access varies by region due to local integrated care board (ICB) implementation decisions and limited NHS specialist service capacity

Until those trials are complete, this study serves as a signal, and the research community is treating it as such

The caloric deficit from the medication plus the increased caloric burn from more intense exercise can continue driving fat loss even as the overall rate slows

Many people find it useful to know the side effects of GLP-1 before taking it

Try deep breathing exercises or briefly numbing the site with ice