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Because that concept, scientifically, made sense, the compound advanced into human clinical trials
They should be offered to men with LUTS and a prostate estimated to be larger than 30 g or PSA greater than 1.4 ng/mL and a high risk of progression
To date, epidemiologic studies and randomized controlled trials have been inconclusive for determining the risk of major adverse cardiovascular events (MACE), such as non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death, with the use of testosterone compared to non-use
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Unknown Long-Term Safety Profile: A short plasma half-life of under 30 minutes in rats and dogs, alongside low bioavailability after intramuscular administration, raises critical questions about what occurs with higher, repeated, or long-term exposures in humans
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