This is achieved after the activation of the transcriptional regulator sterol regulatory element-binding protein 1c (SREBP-1c) that is extremely sensitive to hyperinsulinemia and the carbohydrate response element-binding protein (ChREBP), although its expression is suppressed in individuals with NASH and (iii) the metabolism of intestinal chylomicrons that penetrate the liver through the portal system [9, 10, 17]
(3) Inhibiting Adipose Tissue Inflammation and Improving the Adipose Microenvironment In obesity, adipose tissue develops chronic lowgrade inflammation with abundant release of proinflammatory factors (such as TNF and IL6), disrupting the adipose microenvironment, further worsening fat metabolic abnormalities and insulin resistance, and forming a vicious cycle
doi: 10.1002/ana.23568 118 ZhouDLinYHanZZhangZLinLLinSet al
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Li XL, Duan S, Yuan X, Zhuang T, Qiao J, He
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