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Moderate-to-severe cases may require corticosteroids for acute flares, followed by immunomodulators (azathioprine, 6-mercaptopurine) or biologic agents (anti-TNF therapies, vedolizumab, ustekinumab)

Blood 137:398409 Gallagher ER, Holzbaur ELF (2023) The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy

Nat Plants 6(3):280289 Rediers H, Bonnecarrere V, Rainey PB, Hamonts K, Vanderleyden J, De Mot R (2003) Development and application of a dapB-based in vivo expression technology system to study colonization of rice by the endophytic nitrogen-fixing bacterium Pseudomonas stutzeri A15

(Reference Maged, Elsawah and Abdelhafez8) (effect size (ES): 037 mg/ml, 95 % CI (004, 078)) and Nemati et al

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PMID: 22226834