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Thiamine and its pharmacological forms, as a primary or adjunctive therapy, have been shown to improve symptoms such as nausea, constipation, dysphagia and intestinal dysmotility, in both humans and animals

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Without intrinsic factor, vitamin B12 absorption is significantly impaired, which is why vitamin B12 deficiency is more common in individuals with gastrointestinal disorders that affect intrinsic factor production or absorption