Unlike whole-body knockouts, adipose-specific knockouts did not exhibit increased energy expenditure despite the significant reduction in body weight and fat mass (Supplementary Fig
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Originally developed for type 2 diabetes management, Semaglutide gained widespread attention after the STEP 1 clinical trial (NEJM, 2021) demonstrated an average weight loss of 14.9% of body weight over 68 weeks at the 2.4mg weekly dose
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Kesser noted ( Dtsch Arztebl Int