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Nat Rev Gastroenterol Hepatol (2019) 16(6):37786

Hypoxia induced high expression of thioredoxin interacting protein (TXNIP) in non-small cell lung cancer and its prognostic effect

That long-term option is especially important for people whove struggled with yo-yo dieting or with regaining lost weight

KEY FINDINGS Average weight loss on treatment: 7.9 kg (all GLP-1s) 16.1 kg (newer GLP-1s like semaglutide/tirzepatide) Weight regained after stopping: 0.70.8 kg/month 8.39.6 kg regained in the first year Full return to baseline: 0.9 years (older GLP-1s) 1.7 years (newer GLP-1s) Bottom line: GLP-1s are effective, but without ongoing treatment or structured long-term care, the benefits fade quickly

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Terzepatide, though still in the experimental stage, has demonstrated impressive efficacy in clinical trials