The semaglutide concentration listed on the label already accounts for the presence of additives
No changes in the atherosclerotic lesions size were detected, however, plaque vulnerability was reduced
The ingredients in compounded semaglutide can differ depending on where you get your medication from, so side effects may vary
The practical impact: every pound of muscle lost reduces your daily calorie burn by about six calories at rest
Thus, if you are in the higher dosage range for Wegovy (i.e., 2.4 mg/week), compounded semaglutide may be less expensive on a per-day treatment basis
Key Clinical Evidence Phase 2 Randomized Trial in Obesity (48 weeks) Jastreboff AM et al., New England Journal of Medicine, 2023 ClinicalTrials.gov: NCT04881760 The Phase 2 study evaluated multiple doses of retatrutide versus placebo over 48 weeks