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Unlike other forms of regulated cell death, cuproptosis is characterized by the direct binding of reduced copper (Cu + ) to lipoylated proteins of the tricarboxylic acid (TCA) cycle, most notably dihydrolipoamide S-acetyltransferase (DLAT), together with destabilization of iron-sulfur (Fe-S) cluster proteins such as succinate dehydrogenase complex ironsulfur subunit B (SDHB) 164

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Effect of Ang II on medullary RBF Ang II elicits a paradoxical medullary vasodilatation in normotensive animals, mediated by a secondary activation of vasodilator paracrine agents such as prostaglandins, kinins and NO, rather than to a direct action via AT 2 receptors

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