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Growth factors, such as epidermal growth factor (EGF), transforming growth factor (TGF), platelet-derived growth factor (PDGF), hepatocyte growth factor (HGF), fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), and insulin-like growth factor (IGF), stimulate cancer cell and stromal cell proliferation, migration, and invasion thereby promoting tumor growth, angiogenesis, and metastasis

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