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Both GIP and GLP-1 peptides are rapidly degraded in the gut and serum by the peptidase dipeptidyl peptidase-4 (DPP-4) 7

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The cap-like structure includes some of the conserved amino acids forming pi-cation interactions between Trp72, Arg102, and Trp110 (Figure 4 insets 1 and 2)

Shahwar et al., 2024)

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