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doi: 10.1172/JCI31911 135 Ron-HarelNGhergurovichJMNotarangeloGLaFleurMWTsubosakaYSharpeAHet al

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The brain is constituted by a preponderance of microglia and astrocytes, these glial cells are essential in the Central Nervous System (CNS), with microglia functioning as innate immune cells involved in surveillance and defense, while astrocytes modulate neuronal communication, maintain the extracellular environment, and regulate inflammatory signaling (Garland et al., 2022) Both brain cells are able to produce pro- and anti-inflammatory cytokines (Schwarz and Bilbo, 2012)

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Therefore, the specific duration for tesofensine to produce noticeable effects is not well-established

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