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MATERIALS AND METHODS Animals Male Albino Wistar (200 g) rats, were used in all of the experiments approved by the Local Ethic Committee (at least 10 rats per each experimental group per each period), assessed by observers naive about the given treatment

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Supernatants were removed, diluted 1:1 with 2% acetonitrile in 0.1% formic acid (water), filtered, and analyzed by HPLC-MS/MS

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