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Key finding: 50-70% lipogenesis suppression in primary human adipocytes with increased insulin sensitivity

Trial design Forty-eight healthy participants (79% male, median age: 49 years, BMI: 29.9 kg/m2, body weight: 92 kg) were randomized (3:1) within three cohorts

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Rats received AOD 9604 daily for 6 months and cynomolgus monkeys for 9 months