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The potential interaction between sex hormones and folate may be one of the reasons underlying the gender differences in the suppressive effect of RBC folate, a hypothesis that warrants further validation and exploration in subsequent studies

Vitamin A, well recognized for its importance in immune system functions and cell differentiation, could be a beneficial factor for preventing hyperlipidemia in PCOS

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PBN was also shown to interfere with genes encoding inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and proinflammatory cytokines (Maples et al., 2004

As for using ALA topically, we have to say that its role and effects seem to be less direct than with LA