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Apart from resmetirom, recently approved by the FDA for use in patients with MASH with moderate to advanced liver fibrosis, there are no other therapeutic options for this disease 92

Rather than waiting and hoping the skin catches up on its own, there is now substantial research suggesting that targeted peptide therapy can actively accelerate the skin remodeling process from the inside out

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Lactucopicrin, a sesquiterpene lactone from chicory roots, also activates AMPK/mTOR, reducing p-mTOR, ROS, TG, and intracellular lipid droplets while upregulating PGC1 expression, thereby improving FFA-induced lipid accumulation in HepG2 cells (Tan et al., 2024)

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