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When NAPQI levels are higher than the livers capacity to neutralize, NAPQI will form protein adducts on the mitochondria of liver cells

5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 At present, the pathogenesis of this effect is unknown

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Metformin is a first-line FDA-approved medication for type 2 diabetes that reduces hepatic glucose production and improves insulin sensitivity

The medication remains for 5-7 weeks before it is cleared from the body

But regulators are increasingly concerned about how these drugs are being marketed