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Clinical investigation to support new uses generally requires an Investigational New Drug (IND) application with appropriate chemistry, manufacturing, and controls, nonclinical safety, and human data

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Instead the range of laboratory reference values are shifted downward to reflect those in human subjects as they advance in age

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They are usually few in number and (unlike solar lentigines) have no predilection for sun-exposed sites

2005 specifically tested GHK-Cu on irradiated fibroblasts and found preserved growth-factor expression 7