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All GLP-1 receptor agonists carry a boxed warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and are contraindicated in patients with personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2

Nevertheless, although it is generally accepted that reactive metabolite formation plays an important role in AQ-induced toxicity (Srivastava et al., 2010

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PMID 37834078