Tirzepatide (Mounjaro / Zepbound) prescribing information and approved labeling
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Unlike the first generation GLP-1 medications like semaglutide and liraglutide, tirzepatide works on a second hormone called GIP which increases its efficacy in many patients
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Cagrilintide carries the same proline substitutions at positions 25, 28 and 29 that define pramlintide and suppress fibril formation, together with three further changes, Asn14 to Glu, Val17 to Arg and Tyr37 to Pro, plus acylation of the Lys1 side chain with a C20 fatty diacid through a gamma-glutamate linker
Common ones include nausea, yawning, facial flushing, leg aches, pins and needles , and in some males, spontaneous erections
