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Effect estimates confirmed an increased risk (HR 1.24, 95% CI 1.15 to 1.34), which further supported the robustness of our findings

One important nuance: appetite suppression from retatrutide is not the same as having no appetite

Same GIP

Newer formulations, taken as a pill rather than an injection, could be made for about $16 a month

A general pattern: Cardiovascular outcomes: semaglutide has stronger evidence Weight loss and glucose control: orforglipron is competitive and sometimes leads Convenience: orforglipron is simpler to use Medicare coverage If you have Medicare, you can get a pharmacy benefit card to buy Foundayo for $50 a month

Many people start with semaglutide and switch to tirzepatide if needed, which is a reasonable strategy