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The group of Pei showed that desensitization of KOR-mediated extracellular acidification response was greater upon dynorphin A (1-13) stimulation than U69,593 ((+)-(5,7,8)-N-Methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide) and etorphine (Ling et al., 1998)

Some therapies like PRP injections, physical rehabilitation, and nutritional support may be complementary and enhance results, while others might require timing adjustments or modifications to avoid interference

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Drug design, development and therapy , 9 , 2485-99