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Numerous studies have shown an increase of systemic oxidative stress markers in the lungs of cigarettes smokers and COPD patients without and with inherited AATD

Decreased GSH then results in lipid peroxide accumulation and induction of ferroptosis

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Lifestyle factors including chronic stress, inadequate sleep, excessive alcohol consumption, intense exercise without adequate recovery, and chronic infections also deplete glutathione reserves faster than the body can replenish them through endogenous synthesis

3. Glutathione