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The pancreatic-endocrine-osseous axis involves a potential link between DPP-4, bone, and energy metabolism through the receptor activator of nuclear factor kappa B ligand (RANKL), which induces DPP-4 expression in osteoclasts, leading to decreased GLP-1 levels and increased blood glucose levels

Wan et al., Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis

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Weight loss has been shown to result in improvements in many comorbidities associated with obesity and T2D

Petersen J, Ingemann JVB, Clemmensen C

Most of these peptides are promoted by social media influencers as purported to offer health and wellness benefits, from speeding up recovery after injury to slowing down the ageing process