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Despite their promising effects and low cost, TCAs should be prescribed cautiously because of the side effects such as dry mouth, constipation, urinary retention, and orthostatic hypotension
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Furthermore, ongoing innovations in these therapies hold promise for expanded clinical applications and improved health outcomes
In this regards, weight loss that usually follows initiation of GLP-1RA could contribute to the better cardiovascular outcomes, while initiation of BI is usually accompanied by weight gain [36]
many plans classify GLP-1 as non-covered for weight loss unless diabetes is present