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There is one important exception : Do NOT use GLP-1 agonists if you have: Personal or family history of Medullary thyroid carcinoma History of Multiple endocrine neoplasia type 2 These are rare conditions, but this is a strict contraindication due to safety concerns

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What the Numbers Show Average weight loss by timepoint: Week 12: 8.7% total body weight (19 pounds for 220-pound person) Week 24: 17.3% total body weight (38 pounds for 220-pound person) Week 36: 21.1% total body weight (46 pounds for 220-pound person) Week 48: 24.2% total body weight (53 pounds for 220-pound person) Data from Phase 2 clinical trial, 12mg dose cohort

GLP-1 triggers receptors in the digestive system and brain that reduce hunger cues and slow gastric emptying, which leads to feeling full for longer