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For a peptide like DSIP, the most valuable thing a clinician can learn is how to reason about it honestly : how to read the strength and limits of the evidence, how to interpret regulatory status, how to evaluate sourcing, and how to communicate uncertainty to patients without overpromising

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The Endocrine Society's 2024 clinical practice guideline on pharmacological management of obesity recommended GLP-1 receptor agonists and GIP/GLP-1 receptor agonists (including tirzepatide) as first-line pharmacotherapy for adults with BMI 30, adding clinical weight to coverage arguments

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