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Through several of these interactions, the phosphorylation state of Cx43 is altered, which, in turn, regulates the function of gap junction channels 13,14,15,16,17,18,19

It is generally understood that new biomarkers discovered after application of bioinformatics analysis of omics datasets should be verified using more focused forms of analysis

it reflects the chronic nature of obesity as a metabolic condition

The gut microbiota controls NAFLD by fermenting undigested foodstuff, interacting with intestinal mucosal immune system, and altering intestinal barrier function, leading to signaling changes 117

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But GLP-1 is also produced in the central nervous system, predominantly in the brainstem, and its receptors are expressed in multiple regions of the brain, including the striatum and nucleus accumbens