The detoxification against H 2 O 2 in mitochondria occurs mainly through the GSH redox system, including the glutathione peroxidases (Gpxs) and GSH reductases, as well as the presence of peroxiredoxins (Prxs
As mentioned above, GSH cellular concentrations are regulated by GSH-mediated GCL inhibition (Figures 2, 3)
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