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The cytosolic enzyme is derived from the SHMT1 gene located on chromosome 17p11.2 which is composed of 14 exons that generate three alternatively spliced mRNAs, each of which encode a distinct protein isoform

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604 Granulathiazole A increases the expression of FSP1, GPX4, SLC7A11, while lowering ACSL4 levels by activating the Nrf2/HO-1 pathway, improving the accumulation of -synuclein