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[20] Both subunits of the GST dimer, whether hetero- or homodimeric in nature, contain a single nonsubstrate binding site, as well as a GSH-binding site

8 In noncirrhotic, malnourished patients receiving parenteral nutrition, deficiencies in cysteine (and other amino acids) also can occur, possibly caused by the loss of the first-pass delivery of methionine to the liver and portal blood flow

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In the lungs, the abnormal mucus obstructs the airways and impairs the clearance of bacteria, leading to chronic respiratory infections, inflammation, and progressive lung damage