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Long-term occupational exposure and the diagnosis of dementia

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Bethesda (MD): National Library of Medicine (US)

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Recent studies have indicated that excess Fe 2+ can donate electrons to hydrogen peroxide (H 2 O 2 ) to generate hydroxyl radicals, which have high reactivity with biological molecules, such as proteins, lipids, and nucleic acids, leading to lipid peroxidation and the eventual development of ferroptosis (Stockwell et al., 2017)