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If incubation with compounds is prolonged, superior efficacies can be reached: after 72 h exposure of NTS to compounds 1 and 6 had LD 50 s of 2.2 0.19 and 7.8 2.36 M respectively, whereas 2 had 0.18 0.007 M
It is also contraindicated in those who have a history of cancer, as folic acid can potentially interact with cancer cells
doi: 10.1056/NEJM2003ra020003
Moreover, retinal I/R injury was shown in animal models by transient elevation of intraocular pressure and a mechanistic increase in ROS, and this injury was reversed by the continuous delivery of H 2 saturated eye drops, especially in apoptosis (Oharazawa et al., 2010)
BPC-157 has been shown to influence bleeding time and blood pressure in some studies, which could potentially interact with anticoagulants or blood pressure medications
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