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In the semaglutide group, there was an improvement in quality of life according to the Kansas City Cardiomyopathy Questionnaire (KCCQ-CSS), with a mean change in KCCQ-CSS score of 13.7 points with semaglutide and 6.4 points with placebo (p 1% significantly decreased hospitalisations (aOR 1.33

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This dual approach eating less and burning more may explain the superior weight loss results observed in clinical trials

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The peptides remain biologically active, but the hypothalamic signals they rely on are suppressed