Listen to your body and stop eating when you feel satisfied, not stuffed
Target: 400500 mcg daily by Weeks 48 for maintenance antiinflammatory effects
Key findings include: Mean weight loss of 24.2% (approximately 58 pounds or 26.2 kg) with 12 mg weekly dose after 48 weeks Dose-dependent efficacy across 1 mg, 4 mg, 8 mg, and 12 mg dose groups At 48 weeks, 100% of participants receiving 8 mg or 12 mg achieved at least 5% weight loss 93% of participants on 12 mg achieved 15% or more weight loss , far exceeding current therapeutic benchmarks Greater weight reduction observed in participants with BMI greater than or equal to 35 compared to those with BMI below 35 The magnitude of weight loss approaches that typically observed only with bariatric-metabolic surgery, representing a potential paradigm shift in pharmacological obesity treatment[11]
Retatrutide has shown a broadly positive safety profile in Phase 2 clinical trials
After discontinuation, normal gastric motility returns, which may initially feel like food moves through your system more quickly
It estimated that at 60 weeks, weight regain starts to plateau and is projected to taper off at 75% of the original weight loss
