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That mechanism was validated at meaningful scale: the pivotal trial program supporting FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, one of the larger controlled datasets behind any peptide discussed in this category

Collectively, this study provides a solid foundation for future exploration into the impact of NNMTi-and diet-mediated changes to the gut microbiome in obese and lean populations, as well as future targets to investigate mechanistically with NNMTi treatment