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If you see ice crystals in the pen or if the liquid looks cloudy after being in a very cold spot, do not use it

[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Newton T.D., Bolton S.G., Garcia A.C., Chouinard J.E., Golledge S.L., Zakharov L.N., Pluth M.D

Compounded semaglutide injections must be stored correctly to remain stable and effective

The FDA has proposed permanently excluding tirzepatide (along with semaglutide and liraglutide) from large-scale 503B compounding, and on June 26, 2026 it extended the public comment deadline on that proposal from June 30 to July 30, 2026