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Graphical abstract Similar content being viewed by others Introduction Tirzepatide (LY3298176) is the first peptide dual agonist for type 2 diabetes mellitus (T2DM), which targets both GIPR and GLP1R

Importantly, we demonstrate that the QMP substitutions in DIII of albumin compensate for the reduction in FcRn binding and receptor-mediated cellular recycling caused by enzymatic cleavage of the C-terminal end

Retrieved from Liao, C., Liang, X., Zhang, X., et al

10.1172/jci.insight.141851 21 SandovalD

The most pronounced improvements were in patients with frequent constipation compared to those with frequent diarrhea