E N D Presentation Transcript L-Carnitine Charisma Garcia NFSC 345 Introduction Background Purported Benefits Mechanism of Action Evidence of Benefits Conflicting Research Safety Concerns Professional Position L-Carnitine Essential for Energy Production Naturally Occurs in the Human Body Synthesized in the Liver & Kidneys Derived from the amino acid, Lysine Produces 11-34mg/day (Sufficient to meet all needs!) Dietary L-Carnitine Red meat, dairy, fish, wheat, asparagus, avocado Omnivorous diet: 20-200mg/day (~75% absorbed) No proof of Dietary need exists L-Carnitine as a Supplement Liquid form,Tablets & Capsules Typical Dose: 1000-6000 mg/day ~20% absorbed by the body Generally non-toxic Intended population: Athletes Dieters Purported Benefits Primary Systemic Carnitine Deficiency A recessive gene mutation Cardiovascular Disease Alzheimers Disease Chronic Fatigue In the Elderly Population In Cancer Patients Fat Loss No Evidence EXERCISE PERFORMANCE
Notably, the compound is stable across a wide pH range and fully soluble in aqueous media, unusual properties for a peptide of this size that are attributed to its high proportion of proline and charged residues
WHO Regional Office for the Western Pacific: Manila
Administration of IGF-I acutely activates muscle protein synthesis (Fryburg et al ., 1995), but similarly to GH a 1-year administration did not result in increased lean body mass (Friedlander et al ., 2001)
Uthne K
These medications are contraindicated during pregnancy and breastfeeding when used for weight management, and effective contraception is advised for women of childbearing potential
)
