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Furthermore, when apoptosis and necroptosis fail to occur, caspase-8 can be involved in the activation of caspase-1 and inflammasome to trigger pyroptosis, a strongly proinflammatory cell death modality associated with the release of IL-1 and IL-18 [145, 146]
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Additionally, due to inherent proclivity to hemolytic, thrombotic, and other medically threatening events, G6PD-deficient patients may be limited in treatment options available to them, particularly in the case of COVID-19 infection
K.ThurmanJ
The biology and pathobiology of glutamatergic, cholinergic, and dopaminergic signaling in the aging brain
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