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One of the earliest clinical experiments on the use of MEL in human liver surgery was published as the PORTAL trial, which showed that a single preoperative dose of MEL was safe in patients with planned extensive liver resection (267)

In addition to the acquirement of drug-resistant mutation, the development of cancer stem cells also causes CML persistence and relapse from TKI therapy 12,13,14

doi: 10.1016/j.intimp.2024.113357 181 SharmaATirpudeNVBhardwajNKumarDPadwadY

Esta va de eliminacin especfica que involucra al glutatin desempea papeles fisiolgicamente importantes en la desintoxicacin

[AMA format for Freeman article]: Freeman EW, Sammel MD, Lin H, et al

All surgeries have risks