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Although data from RCTs are probably best suited for comprehensive detection of adverse events due to rigorous safety monitoring, they are also likely to under-represent high-risk patients

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Unlike most other peptides, KPV is not deactivated by digestion, allowing it to be dosed orally and act locally in the GI tract

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Specifically, the IGF-1-PI3K-Akt-mTOR cascade promotes protein synthesis and suppresses protein degradation by phosphorylating downstream FoxO, thereby inhibiting E3 ligases (MuRF1 and atrogin-1) (73,81)