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In addition to conjugation, oxidative metabolism leads to the formation of metabolites such as homovanillic acid, homovanillic alcohol, and 3,4-dihydroxyphenylacetic acid (DOPAC) [38, 55]

Loos, a professor at the University of Copenhagen and affiliated with a research center supported by the Novo Nordisk Foundation (the maker of Wegovy and Ozempic), noted, "The current model explains only 25% of the variability, and further research is needed to uncover the remaining 75%." However, she also expressed optimism, stating, "By combining genetic and clinical information, the era of personalized medicine, where we can select the best drug for each patient, may be upon us."

Mol Psychiatry (2012) 17(3):290314

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Cloots et al., 2024)

Acetyl-L-carnitine also crosses the blood-brain barrier and guards against oxidative damage