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Clinical trials show that Tirzepatide can lead to a 20.9% decrease in body mass over 72 weeks, while Semaglutide results in approximately a 14.9% reduction in a similar timeframe

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Eisenberg, D., Shikora, S.A., Aarts, E., et al

However, discontinuing the medication entirely often leads to weight regain because GLP-1s address physiological drivers of hunger and metabolism that persist even after weight loss

The rate of the all-cause death was also lower in the treatment group (HR: 0.85) [69,70]

Consume high-fiber foods, fermented products, and protein-rich meals