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Free Radic Res (2021) 55:30720

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However, it is always best to take doctors advice

Morning administration is often recommended for several reasons: Consistency with routine : Taking supplements with breakfast helps establish a regular habit, improving adherence Perceived energy support : Although B12 doesn't provide immediate energy, taking it in the morning aligns with the body's natural circadian rhythm when energy demands are higher Avoiding potential sleep concerns : For individuals who report feeling more alert after taking B12, morning dosing eliminates any theoretical risk of evening alertness Absorption considerations are important when choosing timing

To get an indication of how efficiently the catechol estrogens were methylated we also determined the methylated : hydroxylated estrogen ratios