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The foremost limitation is the absence of large-scale, randomized, and well-controlled clinical trials capable of establishing definitive evidence of safety and efficacy in human populations

The molecule is too large

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It mimics the naturally-occurring bile acid in our bodies to help dissolve fat

The molecule makes three changes to the native hormone fragment: a lactam bridge between the aspartate side-chain carboxyl at position 5 and the lysine side-chain amine at position 10, inversion to D-phenylalanine at position 7, and substitution of norleucine for the oxidation-prone methionine at position 4

Gender differences in multiple sclerosis epidemiology and treatment response