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Substantial weight and BMI reductions with lipoic acid supplementation in overweight or obese subjects were also reported in a prior meta-analysis (106)

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Moreover, dysregulated lipid metabolism networks such as ACSL/SCD also drive EMT and migratory properties, and their pharmacologic inhibition selectively impairs CRC cell viability, further broadening the landscape of metabolic vulnerabilities in metastatic CRC [96]

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Ecotoxicol Environ Saf 200:110732