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Despite the absence of efficacy on clinical endpoints, the trials reported biomarker changes consistent with semaglutides hypothesised biological effects
Gastrointestinal side effects caused 5.6% of semaglutide patients to stop their medication entirely, compared to only 2.7% of tirzepatide patients.[1] That's roughly half the dropout rate due to GI issues
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The results will guide future clinical development, as well as a similar study in dogs, according to the researchers
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